Reactivity of nitrosyl complexes of coii and mnii porphyrinates with reactive oxygen species putative formation of peroxynitrite intermediates

Abstract

The thesis primarily focuses on nitric oxide dioxygenase enzymes activity which converts nitric oxide toxic when overly produced to nitrate The reaction of a cobalt porphyrin complex in dichloromethane with nitric oxide NO led to the bent nitrosyl complex of CoNO 8 description It was stable in presence of oxygen gas However it reacts with H2O2 in acetonitrile or THF solution at 226 710 8217 40 194 176 C or 226 710 8217 80 194 176 C to result in the corresponding CoIII nitrate complex The reaction presumably proc...