Comparitive evaluation of osseointegration potential of medical grade sulfonated peek and regular peek

Abstract

AIM newlineTo compare the osseointegration potential of Pure newlinePEEK and Medical grade sulfonated PEEK. newlineMATERIALS AND METHODS newlinePEEK cylinders of Regular PEEK and PEEK Optima newlinecylinders were cut down with thicknesses of 2 mm and newlinediameters of 15 mm with the help of a diamond cutter. All newlinePEEK samples were ultrasonically washed with deionized newlinewater, acetone and ethanol by turns. To optimize newlinesulfonation times, five serial sulfonation times were set, 0 newlinemin (MPEEK), 2 min (SPEEK2), 4 min (SPEEK4), 6 min newline(SPEEK6) and 8 min (SPEEK8), with untreated PEEK as newlinethe control. Medical grade PEEK discs were immersed newlineinto concentrated sulfuric acid (95 98wt. %) under newlinemagnetic stirring at room temperature for different newlinesulfonation times to prepare sulfonated PEEK. At the end newlineof each time point, all SPEEK samples with different newlinesulfonation times were rinsed with acetone for 10 mins, newlinewashed with deionized water for 10 mins under magnetic newlinestirring and finally dried at 37°C. All the samples were newlinesealed in sterile containers. newlineRESULTS newlineThere is a significant difference (plt0.05) in porosity, newlinesurface roughness, wettability, cell viability and cell count newlinein between sulfonated PEEK and Regular peek. newlineCONCLUSION newlineThe present study reveals the use of the sulfonation newlineprocess on PEEK, creates efficient surface modifications. newlineMedical grade PEEK with 6 mins sulfonation is highly newlineefficient and statistically significant (Plt0.05) it has shown newlineefficient porous structure ranging from 1.628µm to newline2.446µm, less residual sulfur content, moderate surface newlineroughness (1.391±0.004), increased hydrophilic property newline(61.50°±1.085°), favorable cytocompatibility, increased newlinecell count at 24hrs, 48hrs and 72hrs newline