Stem Cell Responses Combinatorial Chemistry Based Elucidation of Molecular Signaling

Stem Cell Responses Combinatorial Chemistry Based Elucidation of Molecular Signaling

dc.contributor.guide	Singh, Upma
dc.contributor.guide	Gurudutta, G.U.
dc.creator.researcher	Sharma, Swati
dc.date.accessioned	2022-02-28T07:00:20Z
dc.date.available	2022-02-28T07:00:20Z
dc.date.awarded	2019
dc.date.completed	2018
dc.date.registered	2012
dc.description.abstract	The discovery of hematopoietic stem cells (HSCs) provided a pioneering newlinestep in stem cell research. HSCs are the multipotent adult stem cells, newlinecharacterized by their extensive self-renewal capacity and pluripotency. newlineThey generally reside in the bone marrow niche/ microenvironment in newlineadult mammals (can also be obtained from other sources like peripheral newlineblood and umbilical cord blood) and hierarchically at top of progenitors newlinethat become progressively restricted to several or single lineages newlineincluding myeloid cells (monocyte/macrophage and neutrophil), newlinelymphocytes, red blood cells and megakaryocytes. Spectrums of newlineregulatory signals govern a complex yet dynamic crosstalk between HSCs newlineand its microenvironment (niche) that regulates the molecular signaling newlineand propagates the downstream events by stimulation of several intrinsic newlineand extrinsic factors which decides the stem cell fate. newline
dc.format.accompanyingmaterial	None
dc.format.extent	All Pages
dc.identifier.uri	http://hdl.handle.net/10603/365677
dc.language	English
dc.publisher.institution	Department of Applied Chemistry
dc.publisher.place	Greater Noida
dc.publisher.university	Gautam Buddha University
dc.rights	university
dc.source.university	University
dc.subject.keyword	Chemistry
dc.subject.keyword	Chemistry Applied
dc.subject.keyword	Physical Sciences
dc.title	Stem Cell Responses Combinatorial Chemistry Based Elucidation of Molecular Signaling
dc.type.degree	Ph.D.