Unravelling druggable genetic targets to reprofile FDA approved drugs against Alzheimers disease

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dc.contributor.guideSaraswathy, G R and Raghunadha Reddy, B
dc.coverage.spatial
dc.creator.researcherHemasree, GNS
dc.date.accessioned2023-01-06T04:05:28Z
dc.date.available2023-01-06T04:05:28Z
dc.date.awarded2022
dc.date.completed2022
dc.date.registered2017
dc.description.abstractAlzheimer s Disease (AD), a progressive, irreversible neurodegenerative disorder, affecting the elderly, characterized by dementia and disruptive cognitive functioning, represents one of the highest unmet medical requirements. Neuropathological evidence shows that AD is characterized by the presence of Amyloid Beta (Aand#946;) plaques and neurofibrillary tangles in the hippocampal and cortical regions blocking the synaptic transmission leading to neuronal death. Although there are various complex pathophysiological theories explaining the role of numerous genes and proteins in AD, there exists an arena of genetic bedrocks leading to disruption in regulatory activities resulting in AD progression. Nonetheless the existence of countless genetic evaluations, inconsistencies among various ethnicities contribute to a lacuna in unravelling crucial disease-specific targets opening avenues for exploratory research. newline
dc.description.note
dc.format.accompanyingmaterialDVD
dc.format.dimensions
dc.format.extentxx, 231
dc.identifier.urihttp://hdl.handle.net/10603/437467
dc.languageEnglish
dc.publisher.institutionDepartment of Pharmacy Practice
dc.publisher.placeBengaluru
dc.publisher.universityM S Ramaiah University of Applied Sciences
dc.relation
dc.rightsuniversity
dc.source.universityUniversity
dc.subject.keywordClinical Pre Clinical and Health
dc.subject.keywordPharmacology and Pharmacy
dc.subject.keywordPharmacology and Toxicology
dc.titleUnravelling druggable genetic targets to reprofile FDA approved drugs against Alzheimers disease
dc.title.alternative
dc.type.degreePh.D.

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