Divergent synthesis of azole tailored compounds and their biological and photoluminescence applications

Abstract

Producing a library of diverse compounds with minor structural differences can provide newlinevaluable information related to the structure-activity relationship (SAR), which would not be possible by studying just one molecule. The main goal of the divergent synthesis approach is to efficiently create a collection of valuable compounds, which is different from the traditional methods of making compounds in a linear or convergent way. This approach, known as divergent synthesis, helps select the best compound from the group for its applications. In the newlinecurrent study, the focus is on synthesizing different types of azoles, such as Thiazole Schiff bases, fused tetrazoles, substituted imidazole, and 1H-tetrazoles, and exploring their potential uses in biological and photoluminescence studies. Several methods were utilized to synthesize the derivatives of azole compounds. The synthesized molecules were examined and identified using techniques like 1HNMR, 13CNMR, Mass spectrometry, and IR spectroscopy. After creating a library of molecules, they were evaluated for their potential applications in biology and photoluminescence. The most promising molecule was selected from the preliminary evaluation for further investigation. newlineThiazole Schiff bases were synthesized, and their photoluminescence properties were newlineinvestigated. Among the synthesized compounds, the bromo derivative showed the most promising results in developing fluorescent organic nanoparticles with versatile applications. The compound delivered exceptional results in aggregation-induced emission (AIE), viscochromism, detection of Al3+ions, pH sensing, latent fingerprint detection, and cell imaging. Synthesis of fused azole-derivatives was accomplished using the organo-catalyst 10- newlinecamphor sulfonic acid. Detailed optimization and mechanistic studies were conducted, along newlinewith evaluating the antifungal activity against Candida tropicalis ATCC 10231 for the newlinesynthesized compounds.