a study on combined toxic effects of arsenic and lead in male wistar albino rats protective effect of emblica officinalis and zingiber officinale

Abstract

To evaluate the toxic effects of arsenic (13.8 mg/kg b.wt ) and lead (116.4 mg/kg newlineb.wt ) together in liver, kidney, brain and testis and protective effect of Emblica newlineofficinalis and Zingiber officinalis in male wistar Albino rats. newline2.2. Objectives newlinei. Effects of arsenic (13.8 mg/kg b.wt) and lead (116.4 mg/kg b.wt ) on newlineserum biochemical parameters ( liver and kidney function markers , newlinelipid profile and protection by Emblica officinalis and Zingiber newlineofficinalis. newlineii. Histopathological studies of liver, kidney, brain and testis on arsenic newline(13.8 mg/kg b.wt) and lead (116.4 mg/kg b.wt) toxicity and protection newlineby Emblica officinalis and Zingiber officinalis. newlineiii. To find out the molecular mechanisms underlying the effect of newlineEmblica officinalis and Zingiber officinalis extract on the expression of newlineinflammatory signalling molecules in live, kidney brain and testis. newline 2.3. Ethical consideration: newlineThe study was approved by the Institutional Animal Ethics Committee and met newlinethe Guidelines of the committee for the purpose of control and supervision of newlineexperimentation on animals (CPCSEA) [Approval no. BRULAC/SDCH/SIMATS/IAEC/09- newline2018/009]. newline