Unfolding the potential of transmembrane tnf 945 in cancer therapeutics

Abstract

Tumor necrosis factor alpha TNF 206 177 is involved in maintaining a plethora of immune responses in the human body Although the anti cancer potential of soluble TNF 206 177 was discovered more than a century back its dual nature and tumor promoting ability pose a major hindrance in its acceptance as an anti cancer molecule In contrast the transmembrane TNF 206 177 tmTNF 206 177 the physiological precursor of soluble TNF 206 177 holds the potential of tumor regression without initiating cell proliferation In the...