Synthesis and Electrochemical Study of Drug Metal Complex of Aspirin and Clopidogrel Bisulphate with some Metals

Abstract

Transition metal ions possess different oxidation state property and can interact with a large number of Drugs. These potential of transition metals led to the recent development of drugs which are based on excellent pharmacological and therapeutic effect. synthesis and pre- clinical screening like physio-chemical, anti- microbial and anti-platelet aggregation responses of the transition metal complexes particularly Fe(III), Zn(II), Co(II) and Cu(II) with Aspirin and Clopidogrel is the main object of this work. newlineThe polarographic (DCP) and(DPP) and amperometry were used for qualitative and qualitative estimation of Aspirin and Clopidogrel medicines in pharmaceutical formulations. Aspirin taken in 0.1M Ammonium- Ammonium Chloride buffer at pH 8.0±0.1 produce well defined polarographic wave/peak at E1/2 and Ep -0.90 and -0.92V vs SCE. Clopidogrel taken in 0.02M BRB (supporting electrolyte) and 0.001% gelatin (maximum suppressor) at pH 8.5±0.1, containing 5% of ethanol exhibits gives well defined polarographic wave and peak with potential E1/2 and Ep-1.22 and 1.23 V vs SCE. The waves height was found to be proportional to the concentration of these Drugs. The plot of E vs log i /id-i was a straight line showing the reduction to be reversible. The plateau potential for the polarographic wave of metals are as Zn(II) -1.10V, Fe(III) - 1.40V Co(II)-1.30 V and Cu (II)-0.04V, Vs SCE was applied for carrying out amperometric titration. Metal ion was taken as the titrate and the drug solution was taken as titrant. The end point as located by graphical method revealed metal to drug ratio of 1:2 ratio on the metal: ligand complex equilibrium using polarographic method. newlineThe IR spectra of the titled drugs and their complexes with bio metals viz. Zn, Fe, Co and Cu were recorded in 4000-500 cm-1 region. newline Study of antimicrobial activity of the drug-metal complexes was evaluated by the Kirby-Bauer disk diffusion susceptibility method. The biological activity of these drugs was tested by the antimicrobial study of the above-mention