Role of cell extrinsic and intrinsic factors in regulating mesenchymal stem cell properties

Abstract

Bone marrow niche is composed of cellular and non cellular compartments Cellular environment includes hematopoietic stem cells HSCs non hematopoietic stem cells and their derivatives HSCs maintain the blood cell development HSCs fate is determined by endosteal niche made of osteoblasts and stromal cells and sinusoidal niche made of endothelial cells HSCs proliferation and differentiation is regulated by interaction between the cells directly or indirectly Stromal cells their derivative