Silica and zinc nanostructures for optical biosensor and bioimaging applications

Abstract

Inorganic nanostructures have been extensively studied in the biomedical newlinefield and it presently has limited practical applications due to its lesser newlineoptimization studies for clinical analysis. Particularly, the metal-organic and newlineorganic fluorescent dyes are currently utilized in clinics as imaging probes. newlineNevertheless, it has the drawbacks of photobleaching, shorter lifetime, lower newlinestability and weak targeting efficacy. Hence, to highlight the effectiveness of newlineinorganic nanostructures and to overcome the current limitations in the field of newlinebiomedicine, the present work focuses on silica and zinc-based nanostructures newlinefor optical biosensors and bioimaging applications. These nanostructures were newlinesynthesized by chemical methods and their structural, optical and biological newlinecharacteristics have been analysed. Notably, to promote sustainability in the newlinebiomedical field, in the present work silica nanoparticle has been prepared from newlinerice husk biomass. In the field of fluorescence sensing, the biomass-derived newlinesilica nanoparticle has less attention due to its band gap in the UV region. Thus, newlineto shift the optical band gap towards visible region and to study their potential newlinetowards optical sensing, the sustainable silica was composited with fluorescent newlinematerials. Therefore, the sustainable silica-silver nanocomposite was studied newlinetowards glucoses sensing and silica-zinc nitride nanocomposite was analysed for newlineNADH detection by fluorescence method. The results evidenced the sensitivity newlineand selectivity of SiO2-Ag and Zn3N2-SiO2 sustainable nanocomposite and it can newlinebe recommended as a promising material for diagnostic of diabetes at an earlier newlinestage in the future. Semiconductor materials were extensively newline newline