Formulation Pharmaceutical and Pharmacological evaluation of Herbal granules with Hepatoprotective activity

Abstract

The current study explored the pharmacological approaches to reveal the Herbal newlinegranules with Hepatoprotective activity. Most of the hepatotoxic chemicals damage liver cells newlinemainly by inducing lipid peroxidation and other oxidative damages. Liver possesses a unique newlinemetabolism and plays a pivotal role in the removal of substances from the portal circulation newlinedue to which it is susceptible to toxicity of drugs, xenobiotics, and oxidative stress. The two newlinedistinct pathways in liver metabolism occur via cytochrome p-450 and GSH-peroxidase. The newlinecurrent treatment for hepatotoxicity includes drugs which influence the p-450 enzyme newlinemechanism either by inhibiting (amiodarone, cimetidine, ciprofloxacin, etc.) or inducing newline(rifampicin, carbamazepine, phenobarbital, phenytoin) the metabolic activity of enzymes. newline