Formulatiion Development and Evaluatiion of Orodiispersiible Calcium Channel Blocker Tablets Using Natural Polymers as a Superdiisiintegrant

Abstract

The present study was undertaken to formulate, develop, and evaluate orodispersible tablets of a calcium channel blocker using the direct compression technique, with natural polymers employed as superdisintegrants. The prepared powder blends were evaluated for pre-compression parameters, including angle of repose, bulk density, Carr s compressibility index, and Hausner s ratio, in order to assess flow properties and compressibility. The results indicated satisfactory flow behavior, confirming the suitability of the blends for direct compression. newlineFollowing compression, the tablets were subjected to various post-compression evaluations such as thickness, hardness, friability, weight variation, and drug content to ensure uniformity, mechanical strength, and overall quality. In addition, wetting time, water absorption ratio, and disintegration time were determined to evaluate the rapid disintegration characteristics of the orodispersible tablets. In-vitro drug release studies, along with ex vivo and in vivo evaluations, were performed to assess the drug release profile and therapeutic performance of the formulations. Stability studies further confirmed the consistency and reliability of the tablets over time. newlineDrug excipient compatibility was investigated using infrared spectroscopy (IR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) studies, which revealed no significant interactions. Among all formulations, F6 containing 8% locust bean gum demonstrated superior performance, exhibiting rapid disintegration (29 seconds) and maximum drug release, thereby establishing it as the optimized formulation. newline