Studies on heterocyclic scaffolds and their evaluation for biological significance

Abstract

In the current study, we recognized biologically active compounds based on literature review and by observing present scenario of the medicinal research field. The presented work mainly focuses on four different heterocyclic moieties. The first series for synthesis of 1,4-dihydropyrimidine containing azepino indole-based derivatives. targeted tetrahydro pyrimidine derivatives was achieved by the Biginelli condensation reaction of aldehydes, 1,3-dicarbonyl compound, and Substituted urea. This reaction was carried out in two schemes with the variation of aldehydes and substation of urea. These three derivatives are represented in scheme 1 which are synthesized using azepino indole-based aldehyde, ethyl acetoacetate, and substituted urea whereas compounds were synthesized using a cyclo condensation reaction of substituted benzaldehyde, ethyl acetoacetate, and substituted ammonia mentioned in scheme 2. All the synthetic compounds were tested against antidiabetic studies. The next target was to developed a phenylboronic acid catalyzed synthesis of polysubstituted 1,4-dihydropyridine derivatives. For the synthesis of targeted 1,4-dihydropyridine derivatives were accomplished by the Hantzsch synthesis of aldehydes, 1,3-dicarbonyl compounds, and ammonium acetate to obtained a desire product and check their potency against antioxidant agent. newlineThe third series was developed a L-proline catalysed highly functionalised pyran derivatives. An efficient protocol of one-pot reaction for pyran derivatives via multicomponent reaction using substituted aldehyde, malanonitrile and various active methylene in the presence of a catalytic amount of L-proline using ethanol as a solvent to obtained desire product with high yield. The next target was to developed for synthesis and characterization of new heterocyclic derivatives containing Dihydropyrano[2,3-c] Pyrazoles. The selected synthesized compounds were tested for their in-vitro anti-inflammatory against standard drug diclofenac sodium. Synthesis of compounds was done using conventi