Formulation and Evaluation of Lagenaria Siceraria Granules in the Management of Cardiac Disorders

Abstract

The aim of the study was to formulate and evaluate the granules of Lagenaria Siceraria in the management of cardiac disorders. newlineLagenaria Siceraria (Molina) Standley are commonly known as Bottle gourd, an excellent fruit in the nature having composition of all the essential constituents that are required for normal and good health of humans. It cures pain, ulcers, fever, asthma, and other bronchial disorders. Lagenaria siceraria fruit is traditionally used for its cardioprotective, cardiotonic, general tonic, aphrodisiac activity and acts as purgative and diuretic. newlineCardiovascular disorder is claimed to be relieved following regular intake of bottle gourd juice for about 4-6 months. newlineThe Lagenaria Siceraria fruit were collected from local market and were authenticated by Botanical Survey of India (BSI), Pune. The fruit was further used to prepare juice of it and this juice was evaluated for acute toxicity studies. Preliminary phytochemical evaluation was performed by qualitative analysis, for presence of different chemical constituents. The immediate release granules were formulated by use of extrusion spheronization technique. The formulation of granules was divided in three parts namely A, B and C. The A part comprised of the study of only one superdisintegrant on release pattern. The Part B consisted of use of two superdisintegrants and their effect on the immediate release granules, by use of factorial design, while Part C consisted of use of novel superdisintegrant, to study the effect on granules. Further the optimized batch was traced out from the granules prepared, and that was further used for study, for management of cardiac disorders. The granules were further subjected for salt induced, Dexamethasone induced hypertension and cardio protective against doxorubicin induced cardiotoxicity studies. HPTLC was also performed for the said optimized granules by use of different markers like rutin, quercetin and kaempferol. newlinePhytochemical evaluation suggested the presence of chemical constituents for juice and granul