Development and Evaluation of Some Bioflavonoids from Indigenous Plants

Abstract

The thesis entitled development and evaluation of some bioflavonoids from indigenous plants deals with pharmacognostical, phytochemical and pharmacological investigation of medicinal plants Givotia rottleriformis and Cassia tora, traditionally used for the treatment of chronic inflammatory skin disease psoriasis. A perusal of the literature reveled that only fragmentary information was available on Givotia rottleriformis regarding pharmacognosy, phytochemistry and pharmacological activity by any other researchers. This study was designed first time for the isolation of flavonoids from the selected plants, screening of pharmacological activities of the isolated flavonoids in order to establish its folklore claims and the bioactive flavonoids were promoted to formulation and evaluation for their product performance. Plants are becoming potential source for phytoconstituents with varied pharmacological activities. Identification of such plants of potential use in medicine is of significance and as a prelude to this; it becomes necessary to examine the various pharmacognostical characters of the plant before further investigation. In pharmacognostical studies, the macroscopy, microscopy, histochemical studies of the bark of Givotia rottleriformis, physico-chemical constants, fluorescence analysis and inorganic mineral analysis of G. rottleriformis bark and C. tora leaves were carried out. Pharmacognostical standards obtained during the observation are valuable tools for the identification of the plant material. Morphological study had provided a characteristic identity of bark which was smooth brown estou, bitter taste yielding blood red sap from the bruised bark and leaf which was green in colour, bitter taste with characteristic odour. So, the study can be concluded that the developed formulation containing bioflavonoids can be effective and safety as dietary supplements with health benefits to psoriatic patients, justifying the use of these plants in traditional medicine.