Understanding of calcium signaling pathway mediated by calmodulin and related proteins in neurospora crassa

Abstract

In this study I investigated the cellular functions of calmodulin CaM and related calcium Ca2 signaling proteins in Neurospora crassa The CaM in N crassa is essential for viability therefore I studied its function using the CaM antagonists trifluoperazine TFP and chlorpromazine CPZ I found that the addition of CaM antagonists inhibit growth hyphae branching and sexual development in N crassa I also studied Ca2 ATPases that are important targets of CaM and maintain Ca2 home