Role of microsatellite instability and mismatch repair in prostate carcinoma in North Indian males

Abstract

Prostate cancer is the most frequent cancer among men in most developed countries, newlineyet little is known about its causes. Older age, African ancestry and a positive family newlinehistory of prostate cancer have long been recognized as important risk factors, yet we newlineare only at the early stage of unraveling the complex genetic and envirorunental newlinein?uences on this disease. Over the past 20 years, the body of evidence that genetics newlineplays a key role has grown immensely, ranging from familial aggregation and twin newlinestudies, to family-based linkage studies, to detection of likely functional genes via newlinemutation screening, to molecular epidemiological studies of both rare and common newlinepolymorphisms of candidate genes. However, the evidence also points toward a much newlinemore complex genetic basis of CaP than initially anticipated. newlineAndrogens are implicated in the development of C aP and benign prostatic hyperplasia newline(BPH). The genes involved in androgen pathway and metabolism have been reported newlineto contribute considerably to CaP risk. The increased genetic instability may play newlinesignificant role in molecular carcinogenesis of CaP and DNA repair genes may serve newlineas a biomarker for prognosis, predictor of therapy response, or indeed as target for novel therapy. newline newline