Investigations into expression and regulation of cystatin a and its implication in breast cancer

Abstract

The most perilous attribute of malignant tumors is to metastasize which directly impacts survival Cystatin A CSTA is an endogenous inhibitor of cathepsins which play a significant role in the malignant progression of tumors Loss of CSTA expression shifts the balance towards cathepsins resulting in extensive ECM remodeling tumor invasion and metastasis The precise mechanism behind the loss or regulation of CSTA expression in breast tumors is not known In this study we elucidated the me...