A Comparison Of Muscle Relaxant Profile Of Atracurium With Cisatracurium A Prospective Observational Study

Abstract

Anaesthetic drugs can be credited with the fame of enabling newlineand driving advances in modern surgical procedures. With such newlinerapid advances, concurrent with advances in anesthetic drugs, newlinesurgical handicraft had been developing at an exponential pace. newlineWhile such growth has been progressing, many additional newlineeffects have been desirable for surgeons to prevent morbidity and to newlineease the surgical procedure as well as help in recovery of the newlinepatient. These are neuromuscular blockers and they have newlinerevolutionized the general anesthesia. newlineThe first of the kind was d-tubocurarine, followed by newlinesuccinylcholine. While skeletal muscle relaxants are not new to newlinemankind, they have been used as arrow poison in the ancient days to newlineparalyze and kill the target. In modern times, the pharmacology has newlinebeen extensively studied so that the same can be applied to surgical newlineprocedures. However, these initial prototypic drugs are not used newlinecurrently due to the availability of better drugs with improved newlinesafety margin1. newlineNeuromuscular blockers offer several advantages newlineintraoperatively. They facilitate the performance of longer-duration newlinesurgeries and obliterate voluntary and reflex movements. newline newlineIn the literature, previous investigators have analysed the newlineonset of action, duration and other parameters. Bouju et al., (2017) newlinehave compared atracurium and cisatracurium in critically ill newlinepatients2. Mellinghoff et al., (1996) have compared their newlineneuromuscular blocking ability3. Nogueira et al., (2010) have newlineinvestigated their hemodynamic effects with the use of newlinediphenhydramine and cimetidine4. However, there is lacuna in the newlineliterature regarding simultaneous measurement of hemodynamics newlineand pharmacodynamics of these drugs. Hence this study was newlineformulated newline