identifying the anatomical characters and key molecular mechanisms at transcriptional and posttranscriptional levels to investigate preeclampsia pathogenesis

Abstract

The present study aims to understand the pathogenesis of Preeclampsia at the newlinemolecular level, in the context of transcriptional and post-transcriptional gene newlineregulation and also to study the microscopic anatomical difference occurring in PE, newlineas a part of a compensatory mechanism. newline2.2 Objectives of the Study newlineIn view of the above background, the following objectives have been undertaken to newlineevaluate the key cellular and molecular events involved in the pathogenesis of newlinepreeclampsia. newline1. To investigate the gross anatomical features and microscopic anatomical newlinealterations in placental tissue of late-onset preeclampsia with respect to healthy newlinetissue using light microscopy. newline2. To understand the underlying molecular mechanisms operating at the newlinetranscriptional level, in the pathogenesis of preeclampsia, by studying the expression newlineprofile of Visfatin gene. newline3. To understand the underlying molecular mechanisms operating at the newlinetranscriptional level, in the pathogenesis of preeclampsia, by studying the expression newlineprofile of HO-1 gene. newline4. To study the expression pattern of mi R 200, operating at post- transcriptional newlineregulation of gene expression, in preeclampsia pathogenesis. newline5. To study the expression pattern of mi R 210 operating at post- transcriptional newlineregulation of gene expression, in preeclampsia pathogenesis. newline newline