Studies on the development of Collagen based drug delivery Systems

Abstract

Novel collagen based biomaterials combined with natural and newlinesynthetic co polymers have numerous applications especially in the field of newlineregenerative medicine Development of an appropriate biomaterial for newlineintended application includes integration of specific physic chemical newlineproperties and functionality which induce a significant physiological effect newlineExperiments with a systematic step by step approach to design micropatterned newlinecollagenous composites have been performed with the final aim to newlinedevelop a material suitable for controlled drug release newlineThe initial experiments include the designing of a series of newlinecomposites with biocompatible synthetic poly vinyl alcohol PVA and newlinepoly and#949; caprolactone PCL as well as natural galactomannan polymer newline fenugreek and locust bean gum LBG Composites were crosslinked using newlinegenipin Composites were patterned with various additive compositions newlinecreating a well defined nano size porous structure with a range of newlinehydrophilicity The correlation between physic chemical properties of the newlinecomposites as well as drug release kinetics of insulin with extended residence newlinetime has been elucidated for potential management of diabetes Shaping of the newlinestructural water clusters around the functional groups of collagen with newlinedifferent additive compositions were extensively characterized using a newlinecombination of ATR FTIR UV vis spectroscopy and fluorescence newlinespectroscopy, circular dichroic spectroscopy CD thermoporometry newlineimpedance analysis and refractometry Surface imaging of the composites newlinewere performed using SEM newline newline