An insight into the antibiotic resistance mechanisms employed by gram negative bacteria Escherichia coli and Acinetobacter baumannii and development of an antibiotic resistance prediction model for patients with urinary tract infection

Abstract

Increasing antibiotic resistance (AR) among microbes has emerged as a major public health newlinethreat leading to discussions on post-antibiotic world . This has necessitated increased efforts newlineto tackle AR at a global level. Drug selection pressure from the use of antibiotics is the single newlinemost important driver of development of antibiotic resistance, and the situation is very grim in newlineIndia which carries the highest burden of bacterial diseases in the world. Realizing the gravity of newlineemerging situation, Global Antibiotic Resistance Partnership (GARP) was established in 2009 newlineand one of the major recommendations was lowering resistance-enhancing drug pressure newlinethrough improved antibiotic targeting newline