High Resolution Mass Spectrometry Proteomic Study of Serratia Marcescens and Molecular Dynamics Simulations Analysis of Metallo Beta Lactamase

Abstract

Serratia species are opportunistic gram-negative bacteria classified in the tribe Klebsielleae and the large family Enterobacteriaceae. Serratia marcescens (S. marcescens) is the primary pathogenic species of Serratia. It is the most common species of Serratia found in hospitals, and it is known to cause infections in plants, insects, and animals, including humans. S. marcescens is resistant to a variety of antimicrobials, maybe because of its hospital habitat. Among drug resistant bacteria, S. marcescens is listed as one among the top ten global priority pathogens with multidrug-resistance. Detailed understanding of this organism at the molecular level and also the mechanism of the key proteins involved is necessary to tackle the infections associated with this clinically important bacterium. newline