Synthesis of Heterocyclic Compounds_ Oxazolines and Naphthopyran Derivatives

Abstract

Synthesis of heterocyclic compounds is considered as one of the important and necessary branches of organic chemistry. Furthermore, they have gained massive importance not only from the industrial point of view but also the overall development of human society at large. Heterocyclic compounds that contain N, and O atoms possess a significant role in the field of medicinal as well as pharmaceutical chemistry. Heterocyclic compounds containing Nitrogen, Oxygen, and Sulfur hetero atoms are well studied as they exhibit numerous properties and applications. The main objective of this thesis work is to design and synthesize novel nitrogen and oxygen-containing heterocyclic compounds through readily accessible bench top chemicals. In addition to this, we would like to develop a simple cascade process towards the development of pharmaceutically functionalized scaffolds where C-C, C-O, and C-N bond formation occurs simultaneously without multiple steps and protection/ de protection strategy. The present thesis is divided into three chapters as follows newline newlineChapter 1: This chapter describes the literature review of heterocyclic compounds such as Oxazolines, newlinePyrans, and Naphthopyrans. These heterocyclic skeletons have significant application as antibiotic, antihistamine, anti-migraine, anti-cancer, and as Alzheimer s drug. newlineChapter 2: The second chapter describes the literature review of Xtalfluor-E reagent and its synthetic utility towards Oxazoline synthesis using carboxylic acids and O-silylated amino alcohols. newlineChapter 3: This chapter describes the synthesis of Naphthopyran derivatives from MBH acetates and understanding the mechanism of SN2 and SN2 reaction via Theoretical studies., newline newline