Step Economic Approach for Synthesis of Core Drug like Molecules

Abstract

Chapter one is divided into two parts, the first part we will primarily discuss the concept of newlinetransition metals catalyst, the advantages of 1st row transition metal-oxide nanoparticles from newlinebio-waste resources and so on. Secondly, in this chapter we will also introduce eco-friendly, newlinesustainable, and cost-effective approach for emerging new catalyst and additive-free variety newlineof organic reactions, which is critical in the field of synthetic chemistry. This chapter will newlinealso include an overview of the thesis as well as the objectives of our current research project. newlineChapter two, depicts the importance of transition metals in organic synthesis. Furthermore, newlinethe synthesis of 1st row transition metal-oxide nanoparticles via the biogenic reduction newlinemethod will be emphasized. Additionally, in second part we will summarise the various newlineorganic transformation under transition metal-free condition. newlineIn the third chapter we will describe a multi-component one-pot synthesis of newlinepolyfunctionalized fluorinated and#946;-keto-imidates under transition metal-free conditions. This newlinereaction proceeds via the functionalized alkyne hydration and the intermediate 1,3- newlineketoamino moiety can be achieved by using commercially available cost-effective materials. newlineIn the later stage, we have also described the fluorination of 1,3-ketoamide using selectfluor newline newline12 newline newlineto form a bioactive fluorinated and#946;-keto-imidates. Nevertheless, one pot fluorinated alkyne newlinehydration and its docking study under transition metal-free condition will further highlight newlinethe importance of metal-free chemistry towards the synthesis of bio-active organic newlinemolecules. newlineIn chapter four, we will discuss the catalyst-free intermolecular regioselective [3+2]- newlinecycloaddition of and#945;,and#946;-unsaturated N-arylnitrones with alkenes leading to the functionalized newlineisoxazolidines. Importantly, computational studies confirmed that [3+2]-cycloaddition newlineshowed more favourable results than [5+2]-cycloaddition under catalyst-free conditions. newline newlineIn the fifth chapter, we will mainly focus on the development and synthesis of N,O- newlinecontaining benzo fused heterocyclic compound under catalyst and additive-free conditions newline newlineat ambient temperature. In one pot reaction, O-atom transfer and followed by construction newlineof new C=O, Cand#8722;N, and Cand#8722;O bonds occurred without using an external base and oxidant. newlineFurther, the newly synthesized compounds were studied for their photophysical properties newlineusing ultravioletand#8722;visible absorption and photoluminescence spectroscopy. newline newlineIn chapter six we will discuss a biogenic method for preparation and development of eco- newlinefriendly, inexpensive, recyclable, and single crystalline and#948;-phase manganese-dioxide newline newlinenanoparticles. This work involved the metal catalysed organic transformations wherein newlinealkylation of ketones with primary alcohols and secondly alcohols to form a quinoline newlinederivatives were developed using and#948;-phase manganese-dioxide nanoparticles. We have newlinesuccessfully implemented heterogeneous catalysts for the synthesis of wide range of value newlineadded molecules under ambient conditions in good to excellent yields. newlineIn last chapter, we will collectively summarize overall investigations carried out using newlinetransition metal oxide based nanocatalysts and transition metal-free catalytic systems. newlineFurther, we will try to illustrate and throw light upon the future applications of newly newlinesynthesized biogenic heterogeneous catalysts and catalyst-free pathways for bioactive newlineorganic molecules synthesis and other organic transformations. newline