Visible Light Photocatalyzed Synthesis of Carbon Carbon and Carbon Heteroatom Bond Formation Reactions

Abstract

Despite the significant advances made in the area visible-light photocatalysis, newlineseveral key objectives remain enticing in the realm of synthetic chemistry. These include newlinethe pursuit of readily available starting materials without the need for extensive prefunctionalization, newlinethe development of methodologies with excellent functional group newlinetolerance and broad synthetic applicability, and the ongoing refinement of reaction newlineconditions to further minimize environmental impact. Inspired by the significant newlineachievement in the field of photocatalysis, we have developed new methodologies for the newlineconstruction of carbon-carbon and carbon-heteroatom bonds. This thesis work has focused newlineon the synthesis of bis-(and#61538;-Dicarbonyl)methanes, 1,4-diketones, 2-aryl benzothiazoles, and newlineand#945;,and#946;-unsaturated esters. These synthesized molecules have found utility in various synthetic newlineapplications, particularly in the construction of O-, N-, and S-heterocycles. newlineIn the first work, the synthesis of bis-(and#61538;-dicarbonyl)methanes was achieved newlineusing Ni- and photocatalysis as a synergistic approach with terminal alkenes and and#61538;- newlinedicarbonyls. Notably, vinyl arenes (styrene) emerged as a source of methylene (C1) newlinesynthons to beget bis-(and#946;-dicarbonyl)methanes, marking a new identification in synthon newlinechemistry. Through deuterium labelling studies and further characterization with NMR and newlineMass analyses evidenced the source of methylene from vinyl arenes newline