Development of Cellulose Based Antimicrobial Nanofibers for Advanced Skin Care and Personal Hygiene Products

Abstract

Growing demand for sustainable and high performance biomaterials led newlineto the exploration of cellulose based antimicrobial nanofibers for wound healing and newlinepersonal hygiene applications. This research involved the extraction of Nano newlineFibrillated Cellulose (NFC) from sugarcane bagasse (SCB) and pineapple crown newlineleaves (PCL) by a chemo mechanical approach, facilitating enhanced fibrillation and newlinedispersion for enhanced nanofiber development. Further, Cassia fistula L. extract newlineencapsulated chitosan nanoparticles (CF ChNPs) were synthesized using green newlinemethods, yielding a biocompatible and environmentally friendly antibacterial agent. newlineThematerials have been incorporated into a multilayer electrospun sanitary napkin and newlinewound dressing, engineered for superior absorbency, antibacterial properties, and newlinewound healing efficacy. newlinePolyvinyl alcohol (PVA)/NFC/CF ChNP based nanofibers were assessed newlinefor their biocompatibility, degradation, and efficacy in wound healing applications. newlineThe nanofibers revealed controlled degradation in phosphate buffer saline (PBS) (pH newline7.4), maintaining stability throughout the healing process. In vitro experiments newlinerevealed improved cell viability (above 95%), ascribed to the porous structure and newlinebioactive characteristics of CF ChNPs. In vivo wound healing investigations were newlineconducted utilizing a full thickness excision wound model in Wistar rats to evaluate newlinethe effectiveness of PVA/NFC/CF ChNP based nanofibers to promote tissue newlineregeneration. Analysis of wound contraction revealed a considerably higher closure newlinerate of 99.77 ± 0.19% on day 14, in contrast to the control groups, which exhibited a newlineclosure rate of 90.986 ± 0.54% newline