Heat stress regulation in differential stress tolerance phenotype and comparative expression analysis of different genes in goat

Abstract

The present investigation was undertaken to analyse genetic variation of newlinephysiological response in Jamunapari goats at population level. In this study, total newline1603 observations from 75 sires were recorded for Jamunapari goats during different newlineperiods. The different environmental parameters were recorded during study period. newlineThe THI range varied from 82.00 to 92.08 during hot period, 49.96 to 59.68 during newlinecold period and 65.32 to 74.00 during thermo-neutral period. Physiological responses newlinewere recorded for 695 animals during the hot periods, 617 animals during the cold newlineperiod and 291 animals during thermo-neutral period. The sire means of HSS and newlineHST families were different by 19.737 in RR and 31.438 in HR in the population. RR newlineand HR were significantly different (plt0.01) between heat stress-susceptible and newlinetolerant phenotype. However, RT was not significantly different (plt0.01) between newlineheat stress-susceptible and tolerant phenotype. The heritability of RT, RR and HR newlinewere 0.18 ± 0.058, 0.077 ± 0.044 and 0.307 ± 0.076 respectively, in combined data newlineset. Genetic correlation between RT and HR was high and ranged for 0.866 to 0.990 newlinewith low standard error in hot, cold and combined data set. The h2 newlineof RT, RR and HR newlinewas 0.363 ± 0.119, 0.201 ± 0.097 and 0.362 ± 0.119 with precise error during hot newlineperiod, which was higher than combined period. HR and RR had moderate newlineheritability during hot period. The estimate of heritability (h2 newline) was significant for both newlinehot and cold period. Similarly, heritability for different age group was analysed newlineseparately. The genetic correlation between RT and HR was high and positive during newlinehot and cold period as well as in combined data set. However, the genetic correlation newlinebetween RT with RR and RR with HR was low and negative with high standard error. newlineAbstract newline2 newlineThe phenotypic correlation between RT and HR ranged from 0.132 to 0.190. newlineSimilarly, phenotypic correlation between RT and RR was -0.005 to 0.062. newlineThe objective was designed to analyse genetic polymorphism of he