Formulation and evaluation of herbal preparation against whooping cough

Abstract

Herbal therapy provides rational means for the treatment of many diseases and the plant products are harmless or have least side effects than synthetic drugs. Herbal formulations have reached widespread acceptability as therapeutic agents in India and abroad. Some of the indigenous plants available in India found to show significant antimicrobial activity against Bordetella pertussis. The selected plant (Euphorbia neriifolia Linn.) and their leaf extracts after detailed investigation have shown significant antimicrobial activity against Bordetella pertussis in various fractions. Extracts showing significant activity due to presence of certain active constituents can be effectively formulated into one of the most convenient and promising dosage form i.e. Suspension. Physicochemical parameters of suspension evaluation results indicated physical stability, whereas antimicrobial screening hints the effectiveness of formulations. newline