The Neuroprotective Role of Saraswatharishtam on Scopolamine Induced Memory Impairment in Animal Model As Compared To Piracetam

Abstract

Background: Neuroprotection by nootropic drugs has an excellent potential in the therapy and management of neurodegenerative and neuropsychiatric diseases but memory loss remains challenging. The ayurvedic medicine, Saraswatarishtam utilized in many conditions like anti-aging, to improve memory, immunity, quality of sperm and semen, to treat epilepsy. Aim: To find the possible neuroprotective role of Saraswatarishtam as preventive Ayurveda and Siddha drug to hamper cholinergic dysfunctions and histopathological changes in scopolamine treated rat model. Methods: The present study evaluates the neuroprotective activity of Saraswatharishtam in wistar Swiss albino mice model. The work includes toxicological study, neurobehavioral parameters and in vivo and in-vitro antioxidant study. Results: Saraswatharishtam, was found to ameliorate the memory loss in the elevated plus maze, radial maze and rectangular maze experiments justifying its neuroprotective potential on par with standard medicine Piracetam. Saraswatharishtam was found to be nontoxic at both acute and chronic studies and also showed very promising antioxidant potentials. Conclusion: The current study results suggested that Saraswatarishtam exhibits neuro protective properties against scopolamine induced neuronal damage. This knowledge can put forth the efficacy and validity of such affordable alternative forms of medicine. It is suggested that this medicine could be used as safe, easily affordable, easily available and without any toxicity and needs further translational research to investigate its neuro-protective potential. newline