Effect of vestibular stimulation on behavioral brain immunohistochemical and neurotransmitter changes in Parkinsons disease rats

Abstract

Parkinson s disease is a unique condition that not only affects normal aging but also affects work and social interaction and eventually the personal newlinerelationship. Slow and progressive deterioration, difficulty in the early newlinediagnosis and lack of immediate intervention, makes the initiation of timely newlinemeasures to treat Parkinson s disease. The currently approved drug newlinestrategies are only of symptomatic treatment approach with limited and newlinetemporary relief together with considerable side effects. Hence, it is essential newlineand timely to develop a natural, inexpensive and effective therapy with newlineminimal side effects. Even though the potential of vestibular stimulation in newlineenhancing learning and memory is reported by various studies, its beneficial newlineeffects in treating Parkinson s disease is not systematically explored. Hence newlineproper experimental studies in animal and clinical trials in human are essential newlineto ensure the efficacy and curative effects of vestibular stimulation in PD. This newlinepresent study was hence undertaken to provide an authoritative database for newlineproving the neuroprotective nature of vestibular stimulation and to validate newlinevestibular stimulation as a therapy for enhancement of motor deficit and newlineanxiety symptoms of PD.section. It was observed that warm water vestibular stimulation newlinehas a positive effect on all cognitive, motor and anxiety related parameters. newlineThrough this study it was proven that vestibular stimulation could be an newlineeffective intervention to overcome the structural and functional damage of newlinebrain in Parkinson s disease. Improvement in neurotransmitter levels, newlinehistopathological and immunohistochemical study findings highlight this fact. newlineVestibular stimulation has also alleviated anxiety and improved motor coordination newlinethereby relieving symptoms of Parkinson s disease. All these newlinepositive outcomes have proven that vestibular stimulation for long term of 45 newlinedays can significantly enhance motor co-ordination and decrease anxiety in newlineParkinson s disease and thereby can be used as an alternative therapy