Nitrogen rich Ligands and their Metal Complexes AIE Bioprobe Anticovid and other Biological Applications

Abstract

The interaction of small organic ligand molecules or their metal complexes newlinehaving greater bioactivities and reduced toxic side effects with biological macro newlinemolecules provide one of the attractive areas of coordination chemistry and drug newlinediscovery. Schiff base ligands are one of the most important classes of flexible and newlineversatile polydentate ligands, show high efficiency in chelating transition metal newlineions. Carbohydrazones, thiocarbohydrazones and diaminoguanidinedihydrazones newlineare nitrogen-rich Schiff base ligands, which are prominent in coordination newlinechemistry due to their structurally flexible nature, multiple donor atoms and newlinesignificant pharmacological activity, which make them intriguing subjects of study newlinefor the development of biologically active metal complexes with potential newlinetherapeutic applications. newline SARS-CoV-2 is a single-stranded RNA virus that belongs to the and#120573;- newlinecoronavirus family, responsible for the global covid-19 pandemic that emerged in newlinelate 2019. In silico docking study with SARS-CoV-2 is highly relevant in the quest newlineto understand and combat the covid-19 pandemic. This approach aimed to gain newlineinsights into the binding interactions between viral proteins and potential inhibitors, newlinethereby aiding in the development of targeted therapeutic candidates. Studies have newlinehighlighted the potential of bioactive Schiff bases and their complexes as promising newlinecandidates to bind SARS-CoV-2 Mpro newline. As various studies are progressing in several newlinedirections to develop novel medicines for the treatment of covid-19 disease, we newlineinitiate the possibilities of potential (thio)carbohydrazones and diaminoguanidinebased hydrazones along with their complexes as novel drug candidates against newlineSARS-CoV-2 using in silico studies. newline