Synthesis Biological Activity and Docking Studies of Oxadiazolyl THIOPHENE and ARYL THIADIAZOLYL ARYL DERIVATIVES

Abstract

quotThe work carried out during my research tenure has been collected in the form of a thesis entitled SYNTHESIS, BIOLOGICAL ACTIVITY AND DOCKING STUDIES OF OXADIAZOLYL THIOPHENE AND ARYL, THIADIAZOLYL ARYL DERIVATIVES is classified into four chapters. newline newlineCHAPTER-1: An Overview on Biological Activity and Synthesis of 1,3,4-Thiadiazole Derivatives and 1,3,4-Oxadiazole Derivatives newlineThis chapter describes the introduction, biological applications, and synthesis of 1,3,4-Thiadiazole Derivatives and 1,3,4-Oxadiazole Derivatives objective, and scope of the present research. newlineCHAPTER-II: Synthesis, biological evaluation and docking Studies of new 5-(4-isopropyl phenyl)-1,3,4-Thiadiazol-2-amine derivatives. newlineThis chapter describes the synthesis, Characterization and docking studies of new heterocyclic anlogues of new 5-(4-isopropyl phenyl)-1,3,4-Thiadiazol-2-amine derivatives. all the synthesed compounds are charecterized based on spectral data such as 1H NMR, 13C NMR, IR, Mass and elemental analysis newlineCHAPTER-III: newlinePART-A: Synthesis, Characterization, Docking studies of 5- (Thiophene -2-yl)-1,3,4-oxadiazol-2-amine Derivatives. newlineThis chapter describes the synthesis, Charectarization and docking studies of new amide derivatives of 5- (Thiophene -2-yl)-1,3,4-oxadiazol-2-amine Chemical structures of all the synthesed new compounds are charecterized based on spectral data such as 1H NMR, 13C NMR, IR, Mass and elemental anlaysis newlinePART-B: Synthesis, Characterization and Docking studies of 5-(4-methoxy phenyl) 1,3,4-oxadiazol-2-amine and its new derivatives of symmetrical anhydrides newlineThis chapter describes the synthesis, Charectarization and docking studies of new amide derivatives of 5-(4-methoxy phenyl) 1,3,4-oxadiazol-2-amine. Chemical structures of all the synthesed new compounds are charecterized based on spectral data such as 1H NMR, 13C NMR, IR, Mass and elemental anlaysis newlinePART-C: Synthesis, Characterization, Biological activity, and Molecular Docking studies of new 5-([1, 1 -biphenyl]-4-yl)-1,3,4-oxadiazole-2-amine and their de