Regulatory role of micrornas in sinoatrial node development and function

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dc.contributor.guidekavitha S
dc.coverage.spatialRegulatory role of micrornas in sinoatrial node development and function
dc.creator.researcherPriyadarshan K
dc.date.accessioned2020-11-04T10:59:07Z
dc.date.available2020-11-04T10:59:07Z
dc.date.awarded2019
dc.date.completed2019
dc.date.registeredn.d.
dc.description.abstractBiological pacemaking is possible by modulating ionic currents by gene transfer or by delivering engineered pacemaker cells MicroRNAs are small non coding RNAs involved in posttranscriptional regulation MicroRNAs play a role in regulation of cardiac conduction systems and implicated in arrhythmogenesis We hypothesize the differences in ion channel activity and different action potential shape for different regions of the heart pacemaker atrium ventricle etc are mediated by miRNA regulation The present study hypothesizes the modulation or engineering of stem cells with miRNAs can improve cell based therapies for the treatment of arrhythmia The present study has identified miRNAs playing role in sinoatrial node functioning Using in silico tools the miRNAs targeting the pacemaker genetic network were predicted Nearly 53 miRNAs showed differential expression in sinoatrial node of pig heart Further we have studied the importance of these miRNAs during differentiation of stem cells to cardiac lineage newline
dc.description.note
dc.format.accompanyingmaterialNone
dc.format.dimensions21cm
dc.format.extentxix,150p
dc.identifier.urihttp://hdl.handle.net/10603/305494
dc.languageEnglish
dc.publisher.institutionFaculty of Science and Humanities
dc.publisher.placeChennai
dc.publisher.universityAnna University
dc.relationp.133-148
dc.rightsuniversity
dc.source.universityUniversity
dc.subject.keywordEngineering and Technology
dc.subject.keywordEngineering
dc.subject.keywordEngineering Biomedical
dc.subject.keywordStem cells
dc.subject.keywordTransfer RNA-like structures
dc.titleRegulatory role of micrornas in sinoatrial node development and function
dc.title.alternative
dc.type.degreePh.D.

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