Micro Particulate Delivery System for Anti Tubercular Drugs

Abstract

Tuberculosis (TB) is a chronic infection and is the major cause of mortality and morbidity throughout the world. In spite of the sustained efforts of World Health Organization (WHO), the number of new cases of TB, as well as the mortality related to it are on the rise, due to the emergence of drug resistance, and reduced patient compliance due to dose-related side effects and toxic effects Rifampicin and isoniazid are model drugs and used as first-line drugs treatment of tuberculosis and are included in the list of WHO as a recommended drug regimens for treatment of latent M. tuberculosis infection in adults. Microsphere dug delivery consists of small particles of solids or small droplets of liquids surrounded by walls of natural and synthetic polymer films of varying thickness and degree of permeability acting as a release rate controlling substance and have a diameter upto the range of 0.1 to 200 and#956;m. It is one of the processes to provide the sustained and controlled delivery of drug for long periods of time. newlineBioenhancers are the bioavailability enhancersand#8223;; they themselves do not show any typical drug activity, but when used in combination, they enhance the activity of drug molecule in several ways, including increasing bioavailability of the drug across the membrane, potentiating the drug molecule by conformational interaction, acting as receptors for drug molecule and making target cells more receptive to drugs. newline