evaluation of molecular mechanism of protective effect of quercetin in diabetic complications

Abstract

Diabetic mellitus type 2 (DM-2), a persistent metabolic malady identified by hyperglycemia. Hyperglycemia-mediated oxidative stress (OS), a pivotal factor in the newlineonset of the complications related to diabetes. Additionally, OS is exacerbated by newlineactivation of NF-«B (transcriptor factor), IL-6 (pro-inflammatory cytokine) and caspase-3 (apoptotic activator) influences the origination and advancement of inflammation, newlineeventually leading to cell death. Nrf2 is an important regulator of redox homeostasis, newlinethereby exerting its protective effects by enhancing antioxidant defense against OS. newlineAdditionally, the induction of HO-1, a downstream effector of Nrf2, further contributes to cellular defense by exerting anti-inflammatory and antioxidant effects. Quercetin, a newlineflavonoid with antioxidant and anti-inflammatory attributes, has the potential to influence the cascade of events associated with diabetic complications and therefore has been studied. newline