Characterization and Quantification of Bioactive Phytonutrients in Marine Algae Gracilaria opuntia and Its Pharmacological Evaluation in Hypothyroidism Induced Rat Models

Characterization and Quantification of Bioactive Phytonutrients in Marine Algae Gracilaria opuntia and Its Pharmacological Evaluation in Hypothyroidism Induced Rat Models

dc.contributor.guide	Ganesh.M
dc.coverage.spatial	Hypothyroidism Phytonutrients
dc.creator.researcher	Chandrasekaran.V S
dc.date.accessioned	2025-07-01T10:10:07Z
dc.date.available	2025-07-01T10:10:07Z
dc.date.awarded	2025
dc.date.completed	2025
dc.date.registered	2019
dc.description.abstract	India ancient civilizations are known for medicinal plants wealth recognized for their low risk of adverse reactions Hypothyroidism results from the most common side effects of several medications industrial chemicals and environmental contaminants interacting with the thyroid gland and a decline in function which can result in diabetes Alzheimers disease and other metabolic diseases The present study evaluates the pharmacological activity of bioactive phytonutrients in the ethyl extract of Gracilaria opuntia in hypothyroidism rats induced by propylthiouracil The Gracilaria opuntia extract recovers the T3 and T4 thyroid hormones and better restores colloid tissue in the diseased thyroid glands The Gracilaria opuntia ethyl acetate extract was found to contain phytonutrients like terpenes omega 6 fatty acids aromatic hydrocarbons, and quinoxaline derivatives made as a potent antioxidant and antiinflammatory in hypothyroidism Also the quantity of micronutrients and macronutrients is close to the recommended daily intake Grouped non lethal dose survivors rats received propylthiouracil for the initial fifteen days followed by the Ethyl acetate extract of Gracilaria opuntia three hundred six hundred one thousand two hundred mg per kg the standard drug Levothyroxine treatment alone without propylthiouracil for next fifteen days Aerobic exercise for two groups treated with propylthiouracil and six hundred mg per kg respectively for the next fifteen days Thyroid Lipid profile and levels of cortisol creatinine and endogenous antioxidants were evaluated The ethyl acetate extract of Gracilaria opuntia one thousand two hundred mg per kg and the combination of extract six hundred mg per kg with aerobic exercise exhibited significant restoration of suboptimal thyroid functions due to favourable modulation of the hypothalamic pituitary thyroid axes newline
dc.description.note	Chapter 1 Introduction p.1-40 Chapter 2 Review of Literature p.41-63 Chapter 3 Aim and objectives p.64 Chapter 4 Methodology p.66-102 Chapter 5 Results p.103-202 Chapter 6 Discussion p.203-211 Chapter 7 Summary and Conclusion p.212-220
dc.format.accompanyingmaterial	None
dc.format.dimensions	15 cms
dc.format.extent	1-220
dc.identifier.researcherid
dc.identifier.uri	http://hdl.handle.net/10603/649557
dc.language	English
dc.publisher.institution	College of Pharmacy
dc.publisher.place	Chennai
dc.publisher.university	Sri Ramachandra Institute of Higher Education and Research
dc.relation
dc.rights	self
dc.source.university	University
dc.subject.keyword	Clinical Pre Clinical and Health
dc.subject.keyword	Pharmacology and Pharmacy
dc.subject.keyword	Pharmacology and Toxicology
dc.title	Characterization and Quantification of Bioactive Phytonutrients in Marine Algae Gracilaria opuntia and Its Pharmacological Evaluation in Hypothyroidism Induced Rat Models
dc.title.alternative
dc.type.degree	Ph.D.