Modifier effect of RAAS pathway gene polymorphisms in the progression of chronic kidney in autosomal dominant polycystic kidney disease

Abstract

The development of renal cysts comprise a heterogeneous aetiology and may be broadly categorised into different genetic and non genetic disorders the most common and best understood cause for the renal cystic disease in humans are genetically determined and includes autosomal dominant polycystic kidney disease autosomal recessive polycystic kidney disease and the juvenile nephronophthisis for which the genes or chromosomal locations have been mapped the other cause for autosomal dominant renal cyst formation includes the tuberous sclerosis and von hippel lindau syndrome newline