Dental Skeletal and Non Skeletal Fluorosis in Children of Jaipur District of Rajasthan and Role of Gene Polymorphism

Abstract

Dental, skeletal and non skeletal fluorosis is a major public health problem in India. Fluoride contents in drinking water to enhance the level of fluoride in serum (blood) and urine of the children. The following objectives are newline1. To assess the prevalence of dental, skeletal and non-skeletal fluorosis in children age 6-14 years. newline2. To analyze fluoride level in drinking water, urine and blood samples newline3. To assess the association of COL1A2 gene polymorphism in subjects with dental fluorosis in this preliminary study. newline4. To improve awareness about prevention of fluorosis. newlineThe study of dental, skeletal and non skeletal fluorosis in the children (6-14 years) was conducted in the two blocks (a) Palera, Heerawala, Nayabas, Saipur and Birasana of JamwaRamgarh block, (b) Chitanukalan, Jugalpura, Sunder ka bas ,Peelwa and Sirsali of Amber block of Jaipur district of Rajasthan, India. A total of 150 (93 male and 57 female) children were surveyed. Our data shows that high fluoride concentration in serum level affect the liver function. This finding is also associated with impaired liver function as assessed by biochemical parameters. A case-control study was conducted to investigate the COL1A2 gene polymorphisms with relation to dental fluorosis in children of Jaipur district Rajasthan, India. An association between dental fluorosis and the COL1A2 gene polymorphism was observed in fluoride-exposed populations of Jaipur district of Rajasthan, India. Increasing fluoride level in drinking water is a major risk factor for dental, skeletal and non skeletal fluorosis in the children. A significant increased in level of serum and urine fluoride. The COL1A2 gene polymorphism is associated with an increased risk of fluorosis in the children. newline newline