Studies on the Development of Drug Loaded Collagen Based Biomaterials for Wound Healing and Ocular Therapeutic Applications

Abstract

This study represents a dedicated endeavor towards advancing collagen based biomaterials tailored specifically for wound healing and ocular applications The research journey unfolded with the development of a pioneering collagen HPMC composite scaffold meticulously designed to preserve the native integrity of collagen Through systematic investigations an optimal composition of the scaffold 1equal to 1 point 5 w by w Col HPMC was identified demonstrating significant potential in wound healing and soft tissue engineering Moreover incorporating Povidone iodine PI into the scaffold enabled controlled drug release fostering the proliferation of fibroblast cells and highlighting its promise in regenerative tissue engineering Expanding the scope to ocular drug delivery the study ventured into developing collagen films for this purpose Moxifloxacin loaded Eudragit RL100 nanoparticles were crafted showcasing attributes such as a smooth surface small particle size high encapsulation efficiency and controlled drug release profiles Through meticulous formulation optimization using Box Behnken Design these nanoparticles exhibited promising potential for enhancing therapeutic efficiency in ocular treatments Furthermore the investigation extended to collagen hydrogels particularly focusing on Pluronic registered F127 co functionalized collagen hydrogel complexes for moxifloxacin delivery in corneal applications Leveraging the biocompatibility and moisture retaining capabilities of hydrogels along with the integration of collagen fibers this research aimed to address challenges such as MMP overproduction on the ocular surface ultimately striving to optimize new composites for corneal applications and elevate the treatment of ocular injuries and diseases In essence this comprehensive exploration into collagen based biomaterials signifies a significant step towards transformative advances in regenerative tissue engineering and ocular therapeutics By unlocking the potential of these innovative biomaterials this research promises im