Correlation of Homa Ir And Hba1c In Prediabetic Young Adults

Abstract

ABSTRACT newlineBackground Prediabetes, a state of borderline hyperglycemia, serves as a precursor to type 2 diabetes mellitus (T2DM) and is associated with increased risks of cardiovascular diseases and microvascular complications. Glycated hemoglobin (HbA1c) and insulin resistance (measured by HOMA-IR) are individually recognized as biomarkers for early detection of metabolic dysfunction. However, the correlation between these markers in prediabetic young adults remains underexplored, leaving a critical gap in the early diagnosis and prevention of T2DM. newlineObjective To evaluate the correlation between HbA1c and HOMA-IR in prediabetic young adults and determine whether the combination of these markers enhances the predictive power for metabolic dysfunction compared to their individual use. newlineMethods A cross-sectional study was conducted involving prediabetic young adults aged 18 35 years. Prediabetes was defined based on HbA1c levels (5.7 6.4%) and fasting glucose (100 125 mg/dL). Blood samples were collected to measure fasting glucose, insulin, and HbA1c. HOMA-IR and HOMA-B indices were calculated to assess insulin resistance and and#946;-cell function, respectively. Correlations between HbA1c, HOMA-IR, and HOMA-B were analyzed, and regression models were used to evaluate the combined predictive efficacy of HbA1c and HOMA-IR. newlineResults A significant positive correlation was observed between HbA1c and HOMA-IR (r = 0.65, p lt 0.01). The combined use of HbA1c and HOMA-IR showed higher predictive newlineaccuracy for insulin resistance compared to their individual use (AUC = 0.82 vs. 0.75 and 0.78, respectively). Subgroup analysis revealed that this combined marker approach was particularly effective in individuals with higher BMI (gt25 kg/m²). No significant association was observed between HbA1c and HOMA-B, suggesting that and#946;-cell dysfunction may develop independently of insulin resistance in early prediabetes. newlineConclusion The findings highlight a significant correlation between HbA1c and HOMA-IR in prediabetic young adults, supporting their com