Design Synthesis and Biological Evaluation of Some Antimalarial Agents Effective Against Plasmodium Falciparum

Abstract

In present investigation, a series of 66 compounds were designed and synthesized (M1-M66) using conventional and microwave-assisted technique. The compounds M1-M66 were newlinesubjected to molecular docking on 2O2Y and 3AM5 proteins. All the synthesized compounds newlinewere characterized by IR, 1HNMR and Mass spectroscopy, further, these compounds were newlineevaluated for in-vitro Antimalarial activity. The result of Antimalarial activity revealed that out of entire compounds, one compound M3 exhibited most significant IC50 value of 32.5 newlineand#956;g/ml, while other compounds showed good antimalarial activity. Thus it could be identified as structural lead for further development of new Antimalarial agents. newline