Developing versatile ruthenium systems for catalytic and anticancer applications

Abstract

In ever-evolving applications of Co-ordination Chemistry, this thesis delves into the depths of Ru metal complexes using various N-donor systems. With an initial focus on synthesis and characterization, it aims to shed light on Catalytic and Anticancer applications of the compounds and contribute valuable insights to the existing body of knowledge. The work embodied in the thesis has been divided into seven chapters: newlineChapter-1: Introduction and Scope of Work newlineThe first chapter lays the foundation of importance of selecting Ru as a core metal for exploring the catalytic reactions and for potential anti-cancer applications. The introduction highlights the growing importance of catalysis in various chemical transformations and utilizing transition metal complexes, particularly Ru complexes. In addition, Ru complexes are therapeutic important in areas such as anticancer and their different mode of action makes them attractive candidate for further exploration. This chapter further explores the current state of knowledge surrounding catalysis and biology and realizes the need of research for more efficient systems. This chapter provides a concise overview of Ru catalyzed reactions for organic transformation with a particular emphasis on the acceptorless dehydrogenation of alcohols with amines and olefination of methylazarenes, also the recent advances in the development of Ru based anti-cancer drugs, its current clinical uses and future perspectives. By critically analyzing, this chapter establishes a theoretical framework that serves as a backbone for the subsequent analysis. newlineChapter-2: Design, Syntheses and Characterization of Ruthenium Complexes of Bidentate newlineN, N-ligand as Catalyst for Selective N-alkylation of Amines with Alcohols newlineAlkylated amines are highly bioactive in nature, and nearly 67% of the known drugs have at least one or more N-alkylated molecules. Many drugs used as anti-depressants, anti-parkinson, and analgesics, and hormones like adrenaline contain N-alkylated moieties.