Development and validation of stability Indicating methods for some pharmaceutical Compounds by hplc and its application to Dosage forms

Development and validation of stability Indicating methods for some pharmaceutical Compounds by hplc and its application to Dosage forms

dc.contributor.guide	B. Venkateswara rao,B. Kishore Babu
dc.coverage.spatial
dc.creator.researcher	V L N Balagi Gupta Tiruveedhi
dc.date.accessioned	2023-02-07T10:19:26Z
dc.date.available	2023-02-07T10:19:26Z
dc.date.awarded	2022
dc.date.completed	2022
dc.date.registered
dc.description.abstract	newline This research work was designed to establish and validate a novel stability indicating RP-HPLC method for thecombined determination of Benidipine hydrochloride (BHE) and Nebivolol hydrochloride (NHE) in bulk andtablets, dependent on ICH guidelines.The assay method to analyse BHE and NHE was optimized with isocraticelution using acetonitrile: 0.1M acetate buffer (45:55, pH 5.1), Lichrospher ODS RP-18 column and flow pace of1 ml/min. Total time for single run was 14 min. The injection quantity was 20and#956;l, and was detected at 249nm. Themethod was verified on a concentration series of 1.25-10and#956;g/ml (NHE) and 1.0-10and#956;g/ml (BHE) for precision,accuracy and linearity. newline
dc.description.note
dc.format.accompanyingmaterial	DVD
dc.format.dimensions
dc.format.extent	255 pg
dc.identifier.uri	http://hdl.handle.net/10603/457026
dc.language	English
dc.publisher.institution	Department of Engineering Chemistry
dc.publisher.place	Vishakhapatnam
dc.publisher.university	Andhra University
dc.relation
dc.rights	university
dc.source.university	University
dc.subject.keyword	Chemistry
dc.subject.keyword	Chemistry Applied
dc.subject.keyword	Physical Sciences
dc.title	Development and validation of stability Indicating methods for some pharmaceutical Compounds by hplc and its application to Dosage forms
dc.title.alternative
dc.type.degree	Ph.D.