Bifunctional Chelators For Metal Complexation

Abstract

newlineThe most reliable and most frequently applied method of newlinelinking the metal ion to the biomolecule is by means of a bifunctional newlinechelating agent BFCA The amino acids are used as starting materials for newlinethe preparation of variety of bifunctional chelators Amino acids contain free newlinecarboxylic acid residue can be derivatized for use as BFCs Dpenicillamine is newlinean effective chelator of copper is well absorbed from the gastrointestinal tract newlineand promotes urinary excretion of copper newlineThe coordination ability and diversity of biologically important of newlinevitamin B compounds pyridoxinePN pyridoxalPL and pyridoxamine newlinePM are important in the field of bioinorganic chemistry Pyridoxine PN newlinethe first isolated vitamin B6 component is essential in the diet for the newlinemetabolism of amino acids and the maintenance of body cells Metal newlinecomplexes of vitamin B have been reported to inhibit the growth as well as newlinethe biosynthesis of RNA DNA and protein of E coli B766 newlineAldehydes and ketones are used as building blocks in the syntheses newlineof commercially important compounds including pharmaceuticals and newlinepolymers vanillin and hydroxy benzaldehydes are extensively used as raw newlinematerial to synthesize pancratistatin coumarin neolignan aromatic Cring in newlinetaxane and alibendol derivatives This created interest towards the studies on newlineBifunctional Chelating Agents It is the aim of present work to synthesize newlineBifunctional Chelators of types Amino acid Chelators Vitamin B Chelators newlineand Polyaminocarboxy Chelators and their metal complexes newlineSynthesis acidbase equilibria Xray crystal and experimental newlinecharge density analysis of a double zwitterionic amino acid Schiffbase newlinecompound have been studied in the present work The double zwitterionic newlineamino acid Schiffbase NovanillylideneLhistidine OVHIS was newlinesynthesized by the condensation of Lhistidine with 3methoxy newlinesalicylaldehyde The double zwitterionic nature of the molecule in the solid newlinestate is confirmed through an experimental electron density distribution newlineanalysis newline newline