The G protein coupled estrogen receptor in breast tumors positively associates with ERalpha and constitutes a clinically significant genomic target of estrogen in breast cancer cells

dc.contributor.guide	Limaye, Anil Mukund
dc.coverage.spatial
dc.creator.researcher	Pal, Uttariya
dc.date.accessioned	2023-07-19T10:35:02Z
dc.date.available	2023-07-19T10:35:02Z
dc.date.awarded	2023
dc.date.completed	2023
dc.date.registered	2016
dc.description.abstract	Estrogen exerts its effects on target cells, and tissues via genomic, and non-genomic pathways. The genomic effects of estrogen are mediated by the canonical estrogen receptors, namely ERand#945; and ERand#946;. These are ligand-dependent transcription factors encoded by the ESR1 and ESR2 genes, respectively. The non-genomic effects of estrogen are mediated by membrane-tethered canonical estrogen receptors, ERand#945;36, a splice variant of ERand#945;, or the non-canonical G-protein coupled estrogen receptor (GPER).
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dc.format.accompanyingmaterial	None
dc.format.dimensions
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dc.identifier.uri	http://hdl.handle.net/10603/500168
dc.language	English
dc.publisher.institution	DEPARTMENT OF BIOSCIENCES AND BIOENGINEERING
dc.publisher.place	Guwahati
dc.publisher.university	Indian Institute of Technology Guwahati
dc.relation
dc.rights	self
dc.source.university	University
dc.subject.keyword	Biotechnology and Applied Microbiology
dc.subject.keyword	Life Sciences
dc.subject.keyword	Microbiology
dc.title	The G protein coupled estrogen receptor in breast tumors positively associates with ERalpha and constitutes a clinically significant genomic target of estrogen in breast cancer cells
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dc.type.degree	Ph.D.