Assessment of partakers in tumor micro environment for prognosis of glioma using liquid biopsy a unique clinical approach

Abstract

Gliomas are primary intracranial-tumors with defined molecular-markers available for precise diagnosis. The prognosis of glioma is bleak as there is an overlook of the dynamic crosstalk between tumor cells and components of their micro-environment (ME). Only a few tissue based prognostic markers are established till date for use in the clinic. Based on literature review we identified circulating biomarkers of six important structural and functional components of the microenvironment: hypoxia (iNOS, HSP27, HSP70), angiogenesis (VEGF and ET1), extracellular matrix (MMP14 and ICAM1), cell proliferation (TAU), immune response (IL6 and KYN) and cancer stemness (HMGA1 and Grem1). We then went on to establish the dynamic crosstalk between neoplastic cells and their ME. The aim was to delineate a plausible biomarker panel instead of stand-alone entities that could further enhance the sensitivity and specificity of prognostication in glioma. For this purpose, liquid biopsy was used as a potential tool in disease surveillance and management following surgical intervention. newline