Structure Based Design Synthesis And Evaluation Of New Pyrazole Isoxazole And Quinolone Based Small Molecules As Potent Antitubercular Anticancer Agents

Abstract

The work carried out in my research tenure has been compiled in the form of a thesis entitled newline Structure-based design, synthesis and biological evaluation of new pyrazole, isoxazole, and newlinequinolone based small molecules as potent antitubercular/anticancer agents . The primary newlineobjectives of this work are 1) To design and synthesize new pyrazole and isoxazole-based newlinederivatives and evaluate them for their anti-mycobacterial activity and 2) To design and newlinesynthesize new isoxazole and quinoline based derivatives and evaluate them for apoptosis and antiproliferative activity. newline