Development and Optimization of Eflornithine Hydrochloride Loaded Solid Lipid Microparticles and Nanoparticles Utilizing QbD for Treatment of Hirsutism

Abstract

Hirsutism is a highly distressing and relatively common problem in newlinewomen. Hirsutism is the presence of excess terminal (coarse) hair over the face, newlinechest, stomach, back, upper thighs, or upper arms. Hirsutism is an embarrassing newlinedisease which affects the patient physically as well as mentally. Hirsutism can make newlinewomen extremely self-conscious, threatening both their sense of femininity and self- esteem. All the sufferers want to get rid of this disease at any cost. They are using the newlineexisting treatments without even considering their side-effects; therefore, new newlinetechniques need to be explored. Available alternatives for hirsutism treatment newlineinclude androgen suppression, peripheral androgen blockade, mechanical or newlinecosmetic removal of unwanted hairs and topical application of eflornithine newlinehydrochloride cream. Androgen suppression could be achieved using oral newlinecontraceptive but produces certain side effects like suppression of luteinizing and newlinefollicle stimulating hormones which leads to decrease in ovarian as well as adrenal newlineandrogen production. Another alternative is receptor blocker but they have newlineteratogenic potential. Mechanical or cosmetic removal of unwanted hairs through newlinebleaching, shaving or chemical depilation possibly will be helpful to temporarily newlineelimination of unwanted hairs. Nevertheless, plucking and waxing can cause skin newlineirritation and scarring while shaving may be psychologically unacceptable and lead newlineto blunt hair. Chemical depilatories might cause skin irritation and electrolysis may newlinebe painful and short-wave diathermy can cause scarring. newline