A Novel and Efficient Method for the Synthesis of a Ketoamides Trisubstiued 2 Pytones Polysubstituted Phenols and Phthalimide Derivatives Via Zn Catalyzed Transformations

Abstract

The entire work carried out in the present research programme is categorised into four newlinechapters under the thesis title A novel and efficient method for the synthesis of and#945;ketoamides, trisubstitued 2-pyrones, polysubstituted phenols and phthalimide newlinederivatives via Zn-catalyzed transformations . It consists following chapters newline1. Overall introduction newlineThis chapter explained the detailed introduction of synthesis and biological evaluation of newlineand#945;-Ketoamides, trisubstituted 2-Pyrones, polysubstituted phenols and phthalimide newlinederivatives. newlineKey words: and#945;-Ketoamides, 2-Pyrones, polysubstituted phenols, Phthalimides. newline2. Ligand-Free Zn-catalyzed double carbonylation of aryl iodides with secondary newlineamines: A simple and efficient approach to access and#945;-Ketoamides. newlineAbstract: newlineHerein, we report a double carbonylation of aryl iodides with secondary amines newlineproceeded smoothly under 20 bar pressure of carbon monoxide by using Zn(II)-catalyst, newlineproducing and#945;-ketoamides in good to excellent yields. newlineKey words: Amino carbonylation; carbon monoxide insertion; zinc acetate catalyst, aryl newlineiodides and and#945;-Ketoamides. newline3.One-pot synthesis of trisubstituted 2-pyrones and polysubstituted phenols by a newlineZn-catalyzed cascade of ynone/condensation/elimination reactions newlineAbstract: newlineAn efficient multicomponent method is described for the synthesis of a variety of newlinetrisubstituted 2-pyrones and polysubstituted phenols based on the Zn-catalyzed cascade newlinereactions between ynone compounds and active methylene group containing diesters. newlineThe key strategy used involves the Zn-catalyzed ynone synthesis followed by newlineKnoevenagel condensation and elimination. This methodology is also applied to the newlinesynthesis of poylsubstuited phenols. newlineKey words: trisubstituted 2-pyrones, Knoevenagel condensation, poylsubstuited newlinephenols, salicylates, one-pot. newlineAndhra University, Visakhapatnam newlinex newline4. Zn-catalyzed ligand free double carbonylation reactions with o-diiodoarenes newlinewith anilines and phthalimide derivatives newlineAbstract: newlineZn-catalyzed double carbonytion of o-diiodoarenes with anilines in the presenc